ABSTRACT
Abstract Objective: The clinical cases of patients with multisystem inflammatory syndrome (MIS-C) were analyzed via a systematic review and meta-analysis of the clinical findings, treatments, and possible outcomes of articles retrieved via database searches. Sources: The authors searched the PubMed, Scielo, Web of Science, Science Direct, EMBASA, EBSCO, and Scopus databases for articles containing the keywords "multisystem inflammatory syndrome in children" or "MIS-C" or "PIMS-TS" or "SIMP" and "COVID-19" or "SARS-CoV-2" published between December 1st, 2019 and July 10th, 2021. Patient characteristics, tissue and organ comorbidities, the incidence of symptoms after COVID-19 infection, treatment, and patient evolution in the articles found were evaluated. The data were abstracted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and Newcastle-Ottawa Scale (NOS). Findings: In total, 98 articles (2275 patients) were selected for demographics, clinical treatment, and outcomes of patients diagnosed with MIS-C. The average age of children with MIS-C, 56.8% of whom were male, was of nine years. Fever (100%), gastrointestinal (GI) (82%), and abdominal pain (68%) were the decisive symptoms for the diagnosis of MIS-C. Shock and/or hypotension were common in patients with MIS-C. Cardiac symptoms (66%) predominated over respiratory (39%) and neurological (28%) symptoms. MIS-C treatment followed the common guidelines for treating children with septic shock and Kawasaki disease (KD) and proved to be effective. Conclusions: This meta-analysis highlights the main clinical symptoms used for the diagnosis of MIS-C, the differences between MIS-C and KD, and the severity of the inflammatory process and urgency for hospital care.
ABSTRACT
Gastric cancer (GC) is the fifth most common type of cancer worldwide with high incidences in Asia, Central, and South American countries. This patchy distribution means that GC studies are neglected by large research centers from developed countries. The need for further understanding of this complex disease, including the local importance of epidemiological factors and the rich ancestral admixture found in Brazil, stimulated the implementation of the GE4GAC project. GE4GAC aims to embrace epidemiological, clinical, molecular and microbiological data from Brazilian controls and patients with malignant and pre-malignant gastric disease. In this letter, we summarize the main goals of the project, including subject and sample accrual and current findings
Subject(s)
Humans , Adult , Middle Aged , Aged , Stomach Neoplasms/epidemiology , Brazil , Adenocarcinoma , ProjectsABSTRACT
A comunidade de formigas da área externa ao hospital do Hospital Municipal de Morrinhos, GO, caracterizou-se pelos baixos índices de riqueza, diversidade, dominância e eqüidade de abundância das espécies. Pheidole sp.1, uma espécie poligínica, dominou esse ambiente apesar da coexistência com espécies potencialmente competitivas. A mesma espécie de formiga predominou no interior de praticamente todas as repartições do hospital e sua distribuição espaço-temporal aproximou-se da agregada (variância/média = 1.102, χ2 = 29.38, P < 0.01). Escherichia, Salmonella, Aeromonas, Enterococcus, Staphylococcus e Klebsiella foram os gêneros de bactérias associados a essa espécie de formiga em praticamente todas as repartições do hospital. O unicolonialismo de Pheidole sp.1 tende a potencializar o processo de contaminação e disseminação de agentes infecto-contagiosos. O manejo e controle da espécie devem ser acompanhados de técnicas que reduzam o processo de colonização por novas rainhas e a quantidade de locais de nidificação no interior do hospital.
The external ant community of Hospital Municipal de Morrinhos, in Morrinhos, Goiás State, was characterized by the low rates of richness, diversity, dominance and equity of species abundance. Pheidole sp.1, a polygynic species was numerically dominant in this environment, although it coexists with potentially competitive species. This ant species prevailed within all hospital departments and its space-time distribution was a little aggregated (variance/mean ratio = 1.102, χ2 = 29.38, P < 0.01). Escherichia, Salmonella, Aeromonas, Enterococcus, Staphylococcus and Klebsiella were the bacteria associated to this ant species in nearly all hospital annexes. The unicolonialism of Pheidole sp.1 tends to increase the contamination and dissemination process of infecto-contagious agents. The control and management of this ant species must be followed by practices that reduce the colonization process by other queens and the quantity of site nidification within the hospital.
Subject(s)
Animals , Ants/microbiology , Cross Infection/microbiology , Hospitals, Municipal , Insect Vectors/microbiology , Ants/classification , Brazil , Insect Vectors/classification , Population Density , Species SpecificityABSTRACT
Em Morrinhos, GO, é uma prática comum os produtores rurais distribuírem o leite diretamente aos consumidores. Dessa forma, o objetivo deste trabalho foi avaliar a qualidade microbiológica e físico-químicado leite in natura produzido no município e distribuído diretamente aos consumidores. Foram realizadas análises microbiológicas e físico-químicas do leite cru comercializado clandestinamente no município de Morrinhos - GO. No período de agosto a dezembro de 2005. Foram coletadas e analisadas 21 amostras de leite. Os resultados mostraram 15 (71,4%) amostras com contagens de bactérias mesófilas superiores a 105UFC/mL, para Staphylococcus aureus os níveis foram superiores a 104 UFC/mL em 6 amostras (28,5 %), os índices para bactérias psicrotróficas e coliformes totais ultrapassam 104 UFC/mL; em doze e sete amostras analisadas (58% e 35%), respectivamente. Cinco amostras (24%) estavam contaminadas com coliformes fecais. As análises físico-químicas realizadas foram: densidade, crioscopia, acidez, gordura, extrato seco total, extrato seco desengordurado, alizarol, cloreto, amido, peróxido de hidrogênio, formol, hipoclorito einibidor (antibiótico). Destas, apenas duas (10%) das análises de crioscopia e quatro (19%) das análises de gordura, encontravam-se fora dos padrões. Para o teste com alizarol sete (33%) do total analisado, apresentaram instabilidade e em duas (10%) das amostras, o cloreto estava presente. Considerando as análises microbiológicas e físico-químicas, há a necessidade de se fazer um trabalho de conscientização junto aos produtores, visando melhorar as características higiênico-sanitárias.